Disease mechanisms and genetics of ALS
Despite intensive research efforts, the mechanisms leading to motor neuron degeneration in ALS remain incompletely understood. A major focus of our group is the investigation of biological pathways involved in disease initiation and progression. Using advanced cellular models and genetic analyses, we study both inherited and sporadic forms of ALS with the aim of identifying novel therapeutic targets.
Inflammatory processes in ALS
Growing evidence suggests that immune and inflammatory mechanisms contribute to ALS pathogenesis. We investigate alterations of the immune system through the analysis of blood, tissue, and cerebrospinal fluid to better understand their role in disease onset and progression and to identify novel biomarkers.
Lifestyle and environmental factors
Most ALS cases likely result from an interaction between genetic and environmental factors. Through structured interviews and epidemiological studies, we investigate lifestyle, occupational, and environmental exposures that may contribute to disease risk.
Healthcare research and epidemiology
In addition to basic and translational research, our group is actively involved in studying the healthcare landscape for ALS patients in Austria. Using epidemiological analyses, registry data, and patient-reported outcomes, we evaluate disease trajectories, healthcare delivery, and access to diagnostic and therapeutic services, with the goal of improving patient care.
International collaborations and clinical studies
Research into rare diseases such as ALS can only succeed through international collaboration. Our group is actively involved in the European research networks ENCALS and TRICALS and participates in collaborative research projects and clinical studies aimed at developing and evaluating innovative therapies for people living with ALS.